Host institution: Università Pavia, Italy

ESR9 – Computational modelling and simulation of the cerebellar circuits involved in emotional control

An advanced integration of the data obtained in this ITN with literature will be achieved by computational and robotic modeling. In the framework of the Human Brain Project, of which this host institution is part, a cerebellar model is developed that includes detailed microcircuit connectivity and neuronal properties (Casali et al., 2019; Geminiani et al., 2018, 2019a, 2019b). This background will be taken as the starting point of this project, where the modules corresponding to the cerebellar vermis in relation to emotional control will be investigated. The model will be adapted and extended in order to account for the data obtained by the other participants to this project (e.g. ESR8 for MEA recordings, ESR5-7 for cerebellar structural and functional connectivity) and will be exploited to simulate the data obtained on fear conditioning learning tasks (e.g. ESR1-4). Collaboration with all beneficiaries.

This project will address the concept of a generalized cerebellar algorithm and to determine potential differences in the computation performed in different vermal lobules. Moreover, it will address the role of cerebellum in fear conditioning learning task.

Planned secondments: University of Edinburgh, Thomas Watson / Peter Kind, month 34-36, purpose: modelling of rodent data.